Webezetimibe: Pharmacologic class: Cholesterol absorption inhibitor Therapeutic class: Antihyperlipidemic Pregnancy risk category C Action Inhibits cholesterol absorption in … WebEzetimibe has a unique mechanism of action compared to other classes of lipid-lowering agents. It inhibits the absorption of dietary and biliary cholesterol decreasing the intestinal absorption by 54%. Ezetimibe does not, however, affect triglyceride absorption. The recent cholesterol lowering guidelines, published by the National Cholesterol ...

Product Information for Ezetrol (ezetimibe)

Dosing: Adult. Note: Use may be considered in patients who do not meet cholesterol treatment goals with dietary modification and maximally-tolerated statin therapy (AHA/ACC [Grundy 2024]). Homozygous familial hypercholesterolemia: Oral: 10 mg once daily. Homozygous sitosterolemia: Oral: 10 mg once … See more Note:Use may be considered in patients who do not meet cholesterol treatment goals with dietary modification and maximally-tolerated … See more Hyperlipidemia: Children 5 to 9 years: Limited data available: Oral: 10 mg once daily; dosing based on two studies of monotherapy; a prospective trial (n=17 including six patients … See more May be administered without regard to meals. May be taken at the same time as a statin or fenofibrate. Administer ≥2 hours before or ≥4 hours … See more WebEzetimibe is a novel cholesterol-lowering drug that acts at the brush border of the small intestine. Recent studies have further identified the molecular target as the Niemann-Pick C1-like transporter. Ezetimibe blocks the absorption of dietary and biliary cholesterol and plant sterols resulting in intracellular cholesterol depletion. dnt inspection

Ezetimibe therapy: mechanism of action and clinical update

WebUses. Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. Ezetimibe may be used alone or with other drugs (such as "statins" or ... WebAug 5, 2024 · 4.2 Posology and method of administration. Posology. ... Mechanism of action. Ezetimibe is in a new class of lipid-lowering compounds that selectively inhibit the intestinal absorption of cholesterol and related plant sterols. ezetimibe is orally active and has a mechanism of action that differs from other classes of cholesterolreducing ... WebEzetimibe is a beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer). It has a … dnt is short for: