Phenylacetate-coa
WebAug 1, 2008 · Phenylacetate-CoA ligase (E.C. 6.2.1.30), the initial enzyme in the metabolism of phenylacetate, was studied in Thermus thermophilus strain HB27. Enzymatic activity was upregulated during growth ... WebMar 10, 2015 · The phenylacetate-CoA binds to the PaaA subunit in a hairpin conformation within a ~20Å deep pocket in the protein. The adenine and phenyl moieties at the two ends of the substrate point in the same direction and the phosphates are at the hairpin bend near the protein surface (Figure 2A). The entrance to the substrate-binding pocket is ...
Phenylacetate-coa
Did you know?
http://eawag-bbd.ethz.ch/pac/pac_map.html WebJun 1, 1993 · The enzyme catalysing the first step in the anaerobic degradation pathway of phenylacetate was purified from a denitrifying Pseudomonas strain KB 740. It catalyses the reaction phenylacetate+CoA+ATP → phenylacetyl-CoA+AMP+PPi and requires Mg2+. Phenylacetate-CoA ligase (AMP forming) was found in cells grown anaerobically with …
WebPhenylacetate is derived from the metabolism of phenylalanine, Z-phenylacetaldoxime, styrene, and many other compounds. Phenylacetate aerobic metabolism in fungi usually proceeds by oxidation to homogentisate ( Cox et al., 1996 ), as shown in the left branch below. In bacteria, this rarely occurs, rather the initial step is ligation with CoA. WebApr 26, 2011 · Phenylacetate is first activated through the addition of CoA. The phenylacetyl-CoA is then converted to epoxide by a multicomponent monooxygenase. The aromatic …
WebPhenylacetate-CoA ligase (PA-CoA ligase) catalyzes the first step in aromatic catabolism of phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Often located in a conserved … WebThe Azoarcus evansii gene which codes for phenylacetate-CoA ligase, an enzyme involved in the aerobic degradation of phenylacetate, was isolated from a genomic library, using as the probe a fragment of the gene which encodes the isoenzyme that is induced under anaerobic conditions. By this means both the gene and its flanking sequences were …
WebJul 21, 2010 · Phenylacetyl-CoA is the substrate of a presumed multicomponent oxygenase, PaaABCDE. This oxygenase is a key enzyme of the pathway, proposed to be responsible for the introduction of oxygen into the aromatic ring of phenylacetyl-CoA ( 6, 14, 21 ). First we … We would like to show you a description here but the site won’t allow us.
WebApr 21, 2006 · The acyl-CoA ligand is bound at the protomer-protomer interface with the acyl-thioester moieties inserted into the core of the dimer. The ligand CoA units rest on … the wiezell familyWebCatalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). Involved in the phenylalanine metabolism. 2 publications. Catalytic activity 2-phenylacetate + ATP + … the wife 1996WebPhenylacetate-CoA ligase (E.C. 6.2.1.30), the initial enzyme in the metabolism of phenylacetate, was studied in Thermus thermophilus strain HB27. Enzymatic activity … the wienermobilethe wiesnWebPhenyl acetate is an aromatic ester. Phenyl acetate levels in urine are marker for the diagnosis of some forms of unipolar major depressive disorders. It undergoes Fries … the wieselWebMethyl phenylacetate undergoes decomposition on photolysis in methanol. Methyl phenylacetate acts as acylating agent and causes the enantioselective acylation of beta … the wife 2017 filmWebIn enzymology, a phenylacetate—CoA ligase is an enzyme (EC 6.2.1.30) that catalyzes the chemical reaction. ATP + phenylacetate + CoA AMP + diphosphate + phenylacetyl-CoA. … the wife 161