Trps1 stat3
WebTrichorhinophalangeal syndrome type I (TRPS I) is a condition that causes bone and joint malformations; distinctive facial features; and abnormalities of the skin, hair, teeth, sweat glands, and nails. The name of the condition describes some of the areas of the body that are commonly affected: hair (tricho-), nose (rhino-), and fingers and ... The high level and activity of Stat3 in Trps1 −/− chondrocytes together with the well documented role of Stat3 as a survival promoting signaling molecule (Levy and Lee, 2002) made Stat3 an obvious candidate for controlling chondrocyte survival downstream of Trps1. This assumption was corroborated with several experiments.
Trps1 stat3
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WebSep 1, 2015 · We identified TRPS1 (tricho-rhino-phalangeal-syndrome 1), a repressor of GATA-mediated transcription, and BAT3 (Scythe/BAG6), a nucleo-cytoplasmic shuttling chaperone protein, as new Cath-D-interacting nuclear proteins. Cath-D binds to BAT3 in ER+ BCC and they partially co-localize at the surface of lysosomes and in the nucleus. WebAug 19, 2014 · TRPS1 was down-regulated and STAT3, SOX9 and CTNNB1 were up-regulated in plucked hairs from the patient compared with those in normal controls (Fig. …
WebTrichorhinophalangeal syndrome (TRPS) is an autosomal-dominant congenital hair loss disease characterized by sparse and slow-growing scalp hair, craniofacial and skeletal abnormalities, pear-shaped nose, thin upper lip, brittle and thin toenails, and bilateral brachydactyly of the big toes. WebJan 31, 2013 · TRPS1 is a GATA-type transcription factor that is closely related to human tricho-rhino-phalangeal syndrome (TRPS) types I and III, variants of an autosomal dominant skeletal disorder. ... Stat3 and Runx2. Also, Trps1 protein directly interacts with an activated form of Gli3. In embryonic kidneys, Trps1 functions downstream of BMP7 promoting ...
WebSep 1, 2024 · TRPS1-Stat3-cyclin D1/Bcl2: TRPS1 was a repressor of Stat3 expression, thus controling chondrocyte proliferation and apoptosis by regulating cyclin D1 and Bcl2. [76] … WebMay 3, 2024 · TRPS1 is assumed to be a nuclear regulator of chondrocyte proliferation and differentiation and hair follicles proliferation by homodimerization of the complex with GATA binding protein sequences in ... differentiation and epithelial cell interactions in developing hair follicles by altering many signaling pathways as STAT3 and WNT/β ...
WebTRPS1 Haploinsufficiency Results in Increased STAT3 and SOX9 mRNA Expression in Hair Follicles in Trichorhinophalangeal Syndrome Acta Derm Venereol . 2015 May;95(5):620-1. …
WebTRPS1 was down-regulated and STAT3, SOX9 and CTNNB1 were up-regulated in plucked hairs from the patient compared with those in normal controls (Fig. S2 a, b1). FGF5, TGFB1, STAT6 and STAT1 were not up-regulated (Fig. S2c1). DISCUSSION The TRPS1 gene encodes a zinc-finger transcription factor TRPS1 protein composed of 1,281 amino acids the mc 1488 isWebMay 3, 2024 · Trichorhinophalangeal syndrome (TRPS) is an autosomal dominant disorder resulting from heterozygous mutations of the TRPS1 gene. Common craniofacial abnormalities in TRPS patients include micrognathia, hypoplastic zygomatic arch, high-arched palate, and, occasionally, cleft palate. tiffany hodges tucsonWebAug 19, 2014 · For example, Trps1 is assumed to be a regulator of chondrocyte proliferation and survival via the control of Stat3 expression (7). Indeed, up-regulated expression of STAT3 was observed in the outer root sheath of hair follicles in a TRPS1 patient with a TRPS1 mutation by immunohistochemistry (8). them by tamiaWebIn the current study, through TCGA data mining we identified trichorhinophalangeal syndrome type 1 (TRPS1) as a specific gene for breast carcinoma across 31 solid tumor types. Moreover, high mRNA level of TRPS1 was found in all four subtypes of breast carcinoma including ER/PR-positive luminal A and B types, HER2-positive type, and basal … them by the masculine dandyWebMay 3, 2024 · Molecular analysis of the TRPS1 gene revealed a novel missense mutation in exon 6, (p.Ala932Ser), located in the GATA-type DNA-binding zinc finger domain. ... the mc2 group llc nashville tnWebJul 1, 2008 · TRPS1 is a transcription factor that regulates proliferation and apoptosis of chondrocyte through Stat3 signaling (Suemoto et al., 2007). TRPS1 deficiency has been postulated to impair chondrocyte differentiation in the growth plate and epithelial/mesenchymal cell interactions in developing hair follicles (Nishioka et al., 2008; … the mc10:35the m by radius atlanta